Published in
American Society of Hematology, Blood, 9(132), p. 948-961
DOI: 10.1182/blood-2018-02-832253
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Integrative genomic analysis reveals cancer-associated mutations at diagnosis of CML in patients with high-risk disease
Journal article published in 2018 by
Susan Branford,
Paul Wang 
,
David T. Yeung,
Daniel Thomson,
Adrian Purins,
Carol Wadham ,
Nur Hezrin Shahrin,
Justine E. Marum,
Nathalie Nataren,
Wendy T. Parker,
Joel Geoghegan,
Jinghua Feng,
Naranie Shanmuganathan ,
Martin C. Mueller,
Christian Dietz
and other authors.
,
David T. Yeung,
Daniel Thomson,
Adrian Purins,
Carol Wadham ,
Nur Hezrin Shahrin,
Justine E. Marum,
Nathalie Nataren,
Wendy T. Parker,
Joel Geoghegan,
Jinghua Feng,
Naranie Shanmuganathan ,
Martin C. Mueller,
Christian Dietz
and other authors.
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Abstract
Key Points Next-generation sequencing revealed variants in cancer-associated genes at diagnosis of CML more frequently in patients with poor outcomes. All patients at BC had mutated cancer genes, including fusions, that predated BCR-ABL1 kinase domain mutations in a majority.