Published in
American Society of Hematology, Blood Advances, 12(1), p. 715-727, 2017
DOI: 10.1182/bloodadvances.2016003632
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Clonal evolution underlying leukemia progression and Richter transformation in patients with ibrutinib-relapsed CLL
Journal article published in 2017 by
Sabah Kadri 
,
Jimmy Lee ,
Carrie Fitzpatrick ,
Natalie Galanina ,
Madina Sukhanova ,
Girish Venkataraman ,
Shruti Sharma,
Brad Long ,
Kristin Petras,
Megan Theissen,
Mei Ming,
Yuri Kobzev,
Wenjun Kang ,
Ailin Guo,
Weige Wang
and other authors.
,
Jimmy Lee ,
Carrie Fitzpatrick ,
Natalie Galanina ,
Madina Sukhanova ,
Girish Venkataraman ,
Shruti Sharma,
Brad Long ,
Kristin Petras,
Megan Theissen,
Mei Ming,
Yuri Kobzev,
Wenjun Kang ,
Ailin Guo,
Weige Wang
and other authors.
This paper is made freely available by the publisher.
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Abstract
Key Points Del(18p), together with del(17p)/TP53 mutations, is present at a high frequency before ibrutinib treatment. BTK mutations drive ibrutinib relapse, but del(17p)/TP53 mutations may be dispensable.