Heparin assisted assembly of somatostatin amyloid nanofibrils results in disordered precipitates by hindrance of protofilaments interactions
Journal article published in 2018 by
Durga Dharmadana 
,
Nicholas P. Reynolds ,
Chaitali Dekiwadia,
Charlotte E. Conn ,
Céline Valéry
,
Nicholas P. Reynolds ,
Chaitali Dekiwadia,
Charlotte E. Conn ,
Céline Valéry
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Abstract
We show that the self-assembly of the functional amyloid forming neuropeptide somatostatin-14 is dramatically altered by the presence of GAGs such as heparin and chondroitin sulphate. This work highlights the dangers of using such polymeric sugars as supposedly “inert” amyloid aggregation promotors.