Published in
American Association for the Advancement of Science, Science Signaling, 544(11), 2018
DOI: 10.1126/scisignal.aat6753
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Phosphoproteomic analysis of chimeric antigen receptor signaling reveals kinetic and quantitative differences that affect cell function
Journal article published in 2018 by
Alexander I. Salter 
,
Richard G. Ivey,
Jacob J. Kennedy,
Valentin Voillet,
Anusha Rajan ,
Eva J. Alderman,
Uliana J. Voytovich ,
Chenwei Lin,
Daniel Sommermeyer,
Lingfeng Liu,
Jeffrey R. Whiteaker ,
Raphael Gottardo ,
Amanda G. Paulovich,
Stanley R. Riddell
,
Richard G. Ivey,
Jacob J. Kennedy,
Valentin Voillet,
Anusha Rajan ,
Eva J. Alderman,
Uliana J. Voytovich ,
Chenwei Lin,
Daniel Sommermeyer,
Lingfeng Liu,
Jeffrey R. Whiteaker ,
Raphael Gottardo ,
Amanda G. Paulovich,
Stanley R. Riddell
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Abstract
How potently CAR T cells with CD28 or 4-1BB costimulatory domains stimulate intracellular signaling correlates with treatment efficacy.