American Society for Microbiology, Journal of Virology, 16(92), 2018
DOI: 10.1128/jvi.00687-18
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Influenza A viruses are a major global health threat, not only causing significant morbidity and mortality every year but also having the potential to cause severe pandemic outbreaks like the 1918 influenza pandemic. The viral polymerase is a protein complex which is responsible for transcription and replication of the viral genome and therefore is an attractive target for antiviral drug development. For that purpose it is important to understand the mechanisms of how the virus replicates its genome and how the viral polymerase works on a molecular level. In this report, we characterize the role of the flexible surface-exposed PA 51-72 -loop in polymerase function and offer new insights into the replication mechanism of influenza A viruses.