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immuneACCESS, 2018

DOI: 10.21417/b7ms37

American Society of Hematology, Blood Advances, 9(1), p. 535-544, 2017

DOI: 10.1182/bloodadvances.2016000794

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High-throughput sequencing of the B-cell receptor in African Burkitt lymphoma reveals clues to pathogenesis

Journal article published in 2017 by Katharine A. Lombardo ORCID, David G. Coffey ORCID, Alicia J. Morales, Christopher S. Carlson ORCID, Andrea M. H. Towlerton, Sarah E. Gerdts, Francis K. Nkrumah, J. Neeguaye, Janet Neequaye, Robert J. Biggar, Jackson Orem ORCID, Corey Casper ORCID, Sam M. Mbulaiteye, Kishor G. Bhatia, Edus H. Warren ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Key Points High-throughput sequencing of primary African Burkitt lymphoma tumors suggests disrupted immunoglobulin rearrangements in BL progenitors. Extensive mutation of expressed and nonexpressed IGH rearrangements suggests multiple active mutational processes in BL tumors.