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BioMed Central, Arthritis Research and Therapy, 2(12), p. R57

DOI: 10.1186/ar2969

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Evaluation of the rheumatoid arthritis susceptibility loci HLA-DRB1, PTPN22, OLIG3/TNFAIP3, STAT4 and TRAF1/C5 in an inception cohort

Journal article published in 2010 by Ann W. W. Morgan, YEAR_Consortium, James I. I. Robinson, Philip G. G. Conaghan, Stephen G. G. Martin, Elizabeth Ma A. Hensor, Elizabeth Ma M. Hensor, Michael D. D. Morgan, Lori Steiner, Henry A. A. Erlich, Hock-Chye Gooi, Anne Barton ORCID, Jane Worthington, Paul Emery, The Ukrag Consortium and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

INTRODUCTION: This study investigated five confirmed rheumatoid arthritis (RA) susceptibility genes/loci (HLA-DRB1, PTPN22, STAT4, OLIG3/TNFAIP3 and TRAF1/C5) for association with susceptibility and severity in an inception cohort. METHODS: The magnitude of association for each genotype was assessed in 1046 RA subjects from the Yorkshire Early RA cohort and 5968 healthy UK controls. Additional exploratory subanalyses were undertaken in subgroups defined by autoantibody status (rheumatoid factor [RF] and anti-cyclic citrullinated peptide [CCP]) or disease severity (baseline articular erosions, Health Assessment Questionnaire [HAQ] score and swollen joint count [SJC]). RESULTS: In the total RA inception cohort, HLA-DRB1 shared epitope (SE) (per-allele odds ratio (OR) 2.1, trend P