Published in
American Society of Hematology, Blood, 20(131), p. 2256-2261
DOI: 10.1182/blood-2017-11-817510
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PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia
Journal article published in 2018 by
Yingchi Zhang,
Yufeng Gao,
Hui Zhang,
Jingliao Zhang,
Fuhong He,
Aleš Hnízda,
Maoxiang Qian 
,
Xiaoming Liu,
Yoshihiro Gocho,
Ching-Hon Pui,
Tao Cheng,
Qianfei Wang,
Jun J. Yang,
Xiaofan Zhu,
Xin Liu
,
Xiaoming Liu,
Yoshihiro Gocho,
Ching-Hon Pui,
Tao Cheng,
Qianfei Wang,
Jun J. Yang,
Xiaofan Zhu,
Xin Liu
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Abstract
Key Points AGGF1-PDGFRB is a novel oncogenic fusion gene in Ph-like ALL. Genomic profiling and functional studies identified a novel PDGFRB mutation directly related to TKI resistance.