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American Association for the Advancement of Science, Science Advances, 2(4), 2018

DOI: 10.1126/sciadv.aao1261

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The ancestral retinoic acid receptor was a low-affinity sensor triggering neuronal differentiation

Journal article published in 2018 by Mette Handberg-Thorsager ORCID, Juliana Gutierrez-Mazariegos, Stefan T. Arold ORCID, Eswar Kumar Nadendla, Paola Y. Bertucci ORCID, Pierre Germain, Pavel Tomançak, Keely Pierzchalski ORCID, Jace W. Jones ORCID, Ricard Albalat ORCID, Maureen A. Kane ORCID, William Bourguet, Vincent Laudet ORCID, Detlev Arendt ORCID, Michael Schubert ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Vitamin A–dependent intercellular signaling was originally regulated by a low-affinity sensor and acted in neural development.