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National Academy of Sciences, Proceedings of the National Academy of Sciences, 14(115), p. 3704-3709, 2018

DOI: 10.1073/pnas.1721604115

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Converting Escherichia coli into an archaebacterium with a hybrid heterochiral membrane

Journal article published in 2018 by Antonella Caforio, Melvin F. Siliakus, Marten Exterkate, Samta Jain, Varsha R. Jumde, Ruben L. H. Andringa, Servé W. M. Kengen, Adriaan J. Minnaard ORCID, Arnold J. M. Driessen, John van der Oost
This paper is available in a repository.
This paper is available in a repository.

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Abstract

Significance Escherichia coli has been engineered toward an archaebacterium with an unprecedented high level of archaeal ether phospholipids. The obtained cells stably maintain a mixed heterochiral membrane. This finding challenges theories that assume that intrinsic instability of mixed membranes led to the “lipid divide” and the subsequent differentiation of bacteria and archaea. Furthermore, this study paves the way for future membrane engineering of industrial production organisms with improved robustness.