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Public Library of Science, PLoS ONE, 12(6), p. e27872, 2011

DOI: 10.1371/journal.pone.0027872

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Improving the Alignment Quality of Consistency Based Aligners with an Evaluation Function Using Synonymous Protein Words

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Most sequence alignment tools can successfully align protein sequences with higher levels of sequence identity. The accuracy of corresponding structure alignment, however, decreases rapidly when considering distantly related sequences (