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Elsevier, Lancet Global Health, 2(3), p. e104-e112, 2015

DOI: 10.1016/s2214-109x(14)70289-x

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Orientia, rickettsia, and leptospira pathogens as causes of CNS infections in Laos: a prospective study

Journal article published in 2015 by Sabine Dittrich, Sayaphet Rattanavong, Sue J. Lee, Phonepasith Panyanivong, Scott B. Craig, Suhella M. Tulsiani, Stuart D. Blacksell ORCID, David A. B. Dance ORCID, Audrey Dubot-Pérès, Amphone Sengduangphachanh, Phonelavanh Phoumin, Daniel H. Paris, Paul N. Newton, Others
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Scrub typhus (caused by Orientia tsutsugamushi), murine typhus (caused by Rickettsia typhi), and leptospirosis are common causes of febrile illness in Asia; meningitis and meningoencephalitis are severe complications. However, scarce data exist for the burden of these pathogens in patients with CNS disease in endemic countries. Laos is representative of vast economically poor rural areas in Asia with little medical information to guide public health policy. We assessed whether these pathogens are important causes of CNS infections in Laos.